Psychological, tolerance and Bodily dependence may possibly arise with ongoing use; sufferers with psychological dependence on barbiturates may well build a Bodily dependence on barbiturates by growing or reducing the dosage interval without consulting a medical doctor
pentobarbital will lessen the level or outcome of theophylline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
Use Caution/Keep an eye on. CYP3A4 inducers may possibly raise the metabolism of clopidogrel to its active metabolite. Observe clients for likely increase in antiplatelet effects when CYP3A4 inducers are utilized together with clopidogrel
pentobarbital will lower the level or result of bosentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Not known.
pentobarbital will decrease the level or result of carbamazepine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will increase toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers may well improve the metabolism of ifosfamide to its Lively alkylating metabolites.
With therapeutic doses of TCAs, barbiturates maximize metabolism and decrease blood concentrations of TCAs.
pentobarbital will minimize the level or impact of eplerenone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unknown.
pentobarbital will reduce the extent or outcome of etonogestrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will lower the level or influence of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Knowledge are presently not accessible to Examine influence of barbiturates when forceps delivery or other intervention is necessary; also, knowledge usually are not available to find out the influence of those barbiturates on the later advancement, development, and purposeful maturation of the child
Comment: Barbiturates may possibly maximize adverse effects, which include respiratory depression, produced by poisonous click here doses of TCAs. With therapeutic doses of TCAs, barbiturates improve metabolism and decrease blood concentrations of TCAs.
pentobarbital will reduce the level or influence of nimodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Mysterious.
pentobarbital will minimize the extent or outcome of mifepristone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers have not been examined, coadministration not recommended by maker